HMBPP-deficient Listeria mutant immunization alters pulmonary/systemic responses, effector functions, and memory polarization of Vγ2Vδ2 T cells

Whereas infection or immunization of humans/primates with microbes coproducing HMBPP/IPP can remarkably activate Vγ2Vδ2 T cells, in vivo studies have not been done to dissect HMBPP- and IPP-driven expansion, pulmonary trafficking, effector functions, and memory polarization of Vγ2Vδ2 T cells. We def...

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Veröffentlicht in:J Leukoc Biol
Hauptverfasser: Frencher, James T., Shen, Hongbo, Yan, Lin, Wilson, Jessica O., Freitag, Nancy E., Rizzo, Alicia N., Chen, Crystal Y., Chen, Zheng W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Leukocyte Biology 2014
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Spotlight on Leading Edge Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226791/
https://ncbi.nlm.nih.gov/pubmed/25114162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.6HI1213-632R
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