Profiling Dose-Dependent Activation of p53-Mediated Signaling Pathways by Chemicals with Distinct Mechanisms of DNA Damage

As part of a larger effort to provide proof-of-concept in vitro-only risk assessments, we have developed a suite of high-throughput assays for key readouts in the p53 DNA damage response toxicity pathway: double-strand break DNA damage (p-H2AX), permanent chromosomal damage (micronuclei), p53 activa...

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Publicado en:Toxicol Sci
Autores principales: Clewell, Rebecca A., Sun, Bin, Adeleye, Yeyejide, Carmichael, Paul, Efremenko, Alina, McMullen, Patrick D., Pendse, Salil, Trask, O. J., White, Andy, Andersen, Melvin E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
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114
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226763/
https://ncbi.nlm.nih.gov/pubmed/25078064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu153
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