Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory Complex-I activity via Bcl-2 family proteins

Although the p53 tumor suppressor/transcription factor often accumulates in the cytoplasm of healthy cells, limited information is available on the cytoplasmic function of p53. Here, we show that cytoplasmic p53 suppresses cell invasion by reducing mitochondrial reactive oxygen species (ROS) levels....

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Kim, Eun Mi, Park, Jong Kuk, Hwang, Sang-Gu, Kim, Wun-Jae, Liu, Zheng-Gang, Kang, Sang Won, Um, Hong-Duck
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226696/
https://ncbi.nlm.nih.gov/pubmed/25115399
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