The Synthetic Tryptanthrin Analogue Suppresses STAT3 Signaling and Induces Caspase Dependent Apoptosis via ERK Up Regulation in Human Leukemia HL-60 Cells

Tryptanthrin is a natural product which has been reported to have several medicinal properties. In this study, we tried to investigate the detailed molecular mechanism of its bromo analogue (TBr), a potent cytotoxic agent in the induction of cancer cell death. It was found that TBr primarily targets...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Pathania, Anup S., Kumar, Suresh, Guru, Santosh K., Bhushan, Shashi, Sharma, Parduman R., Aithagani, Sravan K., Singh, Parvinder P., Vishwakarma, Ram A., Kumar, Ajay, Malik, Fayaz
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226462/
https://ncbi.nlm.nih.gov/pubmed/25383546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110411
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