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Detoxification of aristolochic acid I by O-demethylation: Less nephrotoxicity and genotoxicity of aristolochic acid la in rodents

Ingestion of aristolochic acids (AA) contained in herbal remedies results in aristolochic acid nephropathy (AAN), which is characterized by chronic renal failure, tubulointerstitial fibrosis and urothelial cancer. AA I and AA II, primary components in AA, have similar genotoxic potential, whereas on...

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Détails bibliographiques
Publié dans:Int J Cancer
Auteurs principaux: Shibutani, Shinya, Bonala, Radha R., Rosenquist, Thomas, Rieger, Robert, Suzuki, Naomi, Johnson, Francis, Miller, Frederick, Grollman, Arthur P.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226239/
https://ncbi.nlm.nih.gov/pubmed/20039324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.25141
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