Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition

BACKGROUND: The activity of P-glycoprotein (Pgp) and multidrug resistance related protein 1 (MRP1), two membrane transporters involved in multidrug resistance of colon cancer, is increased by high amounts of cholesterol in plasma membrane and detergent resistant membranes (DRMs). It has never been i...

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Bibliografiske detaljer
Udgivet i:Mol Cancer
Main Authors: Gelsomino, Giada, Corsetto, Paola A, Campia, Ivana, Montorfano, Gigliola, Kopecka, Joanna, Castella, Barbara, Gazzano, Elena, Ghigo, Dario, Rizzo, Angela M, Riganti, Chiara
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225767/
https://ncbi.nlm.nih.gov/pubmed/24225025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-137
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