Targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency

INTRODUCTION: We previously demonstrated that a single-chain fragment variable (scFv) specific to collagen type II (CII) posttranslationally modified by reactive oxygen species (ROS) can be used to target anti-inflammatory therapeutics specifically to inflamed arthritic joints. The objective of the...

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Bibliographic Details
Published in:Arthritis Res Ther
Main Authors: Hughes, Chris, Sette, Angelica, Seed, Michael, D’Acquisto, Fulvio, Manzo, Antonio, Vincent, Tonia L, Lim, Ngee Han, Nissim, Ahuva
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225686/
https://ncbi.nlm.nih.gov/pubmed/25029910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4613
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