Human single-chain variable fragment that specifically targets arthritic cartilage

OBJECTIVE: To demonstrate that posttranslational modification of type II collagen (CII) by reactive oxygen species (ROS), which are known to be present in inflamed arthritic joints, can give rise to epitopes specific to damaged cartilage in rheumatoid arthritis (RA) and osteoarthritis (OA) and to es...

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Detalhes bibliográficos
Main Authors: Hughes, Chris, Faurholm, Bjarne, Dell'Accio, Francesco, Manzo, Antonio, Seed, Michael, Eltawil, Noha, Marrelli, Alessandra, Gould, David, Subang, Christina, Al-Kashi, Adam, De Bari, Cosimo, Winyard, Paul, Chernajovsky, Yuti, Nissim, Ahuva
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2010
Assuntos:
Experimental Arthritis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905615/
https://ncbi.nlm.nih.gov/pubmed/20131274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27346
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