Cross-Tissue and Tissue-Specific eQTLs: Partitioning the Heritability of a Complex Trait

Top signals from genome-wide association studies (GWASs) of type 2 diabetes (T2D) are enriched with expression quantitative trait loci (eQTLs) identified in skeletal muscle and adipose tissue. We therefore hypothesized that such eQTLs might account for a disproportionate share of the heritability es...

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Detalles Bibliográficos
Publicado en:Am J Hum Genet
Main Authors: Torres, Jason M., Gamazon, Eric R., Parra, Esteban J., Below, Jennifer E., Valladares-Salgado, Adan, Wacher, Niels, Cruz, Miguel, Hanis, Craig L., Cox, Nancy J.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225593/
https://ncbi.nlm.nih.gov/pubmed/25439722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2014.10.001
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