Thrombin mutant W215A/E217A treatment improves neurological outcome and attenuates central nervous system damage in experimental autoimmune encephalomyelitis

Multiple sclerosis (MS) is a neuroinflammatory disease characterized by demyelination and axonal damage of the central nervous system. The pathogenesis of MS has also been linked to vascular inflammation and local activation of the coagulation system, resulting in perivascular fibrin deposition. Tre...

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Vydáno v:Metab Brain Dis
Hlavní autoři: Verbout, Norah G., Yu, Xiaolin, Healy, Laura D., Phillips, Kevin G., Tucker, Erik I., Gruber, András, McCarty, Owen J.T., Offnerr, Halina
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225189/
https://ncbi.nlm.nih.gov/pubmed/24810631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11011-014-9558-8
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