Potential implications of CYP3A4, CYP3A5 and MDR-1 genetic variants on the efficacy of Lopinavir/Ritonavir (LPV/r) monotherapy in HIV-1 patients

INTRODUCTION: Several genetic single nucleotide polymorphisms (SNPs) in biotransformation enzymes (CYP3A4, CYP3A5) or transporter proteins (multidrug resistance MDR1 gene product, P-gp) are involved in PI metabolism so that PI pharmacokinetics is characterized by a large inter-individual variability...

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Bibliographic Details
Published in:J Int AIDS Soc
Main Authors: Berno, Giulia, Zaccarelli, Mauro, Gori, Caterina, Tempestilli, Massimo, Pucci, Luigia, Antinori, Andrea, Perno, Carlo Federico, Paolo Pucillo, Leopoldo, D'Arrigo, Roberta
Format: Artigo
Language:Inglês
Published: International AIDS Society 2014
Subjects:
Poster Sessions – Abstract P057
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224892/
https://ncbi.nlm.nih.gov/pubmed/25394094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7448/IAS.17.4.19589
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