SR-A and SREC-I binding peptides increase HDAd-mediated liver transduction

Helper-dependent adenoviral (HDAd) vectors can mediate long-term, high-level transgene expression from transduced hepatocytes without inducing chronic toxicity. However, vector therapeutic index is narrow because of a toxic acute response with potentially lethal consequences elicited by high vector...

Full description

Saved in:
Bibliographic Details
Published in:Gene Ther
Main Authors: Piccolo, Pasquale, Annunziata, Patrizia, Mithbaokar, Pratibha, Brunetti-Pierri, Nicola
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224584/
https://ncbi.nlm.nih.gov/pubmed/25119377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2014.71
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items