SR-A and SREC-I binding peptides increase HDAd-mediated liver transduction

Helper-dependent adenoviral (HDAd) vectors can mediate long-term, high-level transgene expression from transduced hepatocytes without inducing chronic toxicity. However, vector therapeutic index is narrow because of a toxic acute response with potentially lethal consequences elicited by high vector...

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Vydáno v:Gene Ther
Hlavní autoři: Piccolo, Pasquale, Annunziata, Patrizia, Mithbaokar, Pratibha, Brunetti-Pierri, Nicola
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224584/
https://ncbi.nlm.nih.gov/pubmed/25119377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2014.71
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