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Differential Effect of HDAC3 on Cytoplasmic and Nuclear Huntingtin Aggregates
Histone deacetylases (HDACs) are potential therapeutic targets of polyglutamine (pQ) diseases including Huntington’s disease (HD) that may function to correct aberrant transcriptional deactivation caused by mutant pQ proteins. HDAC3 is a unique class 1 HDAC found in both the cytoplasm and in the nuc...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4224383/ https://ncbi.nlm.nih.gov/pubmed/25380050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111277 |
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