Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning

The glycosyltransferase gene, Ext1, is essential for heparan sulfate production. Induced deletion of Ext1 selectively in Mx1-expressing bone marrow (BM) stromal cells, a known population of skeletal stem/progenitor cells, in adult mice resulted in marked changes in hematopoietic stem and progenitor...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Saez, Borja, Ferraro, Francesca, Yusuf, Rushdia Z., Cook, Colleen M., Yu, Vionnie W. C., Pardo-Saganta, Ana, Sykes, Stephen M., Palchaudhuri, Rahul, Schajnovitz, Amir, Lotinun, Sutada, Lymperi, Stefania, Mendez-Ferrer, Simon, del Toro, Raquel, Day, Robyn, Vasic, Radovan, Acharya, Sanket S., Baron, Roland, Lin, Charles P., Yamaguchi, Yu, Wagers, Amy J., Scadden, David T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224192/
https://ncbi.nlm.nih.gov/pubmed/25202142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-593426
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