Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow

Production of the cells that ultimately populate the thymus to generate α/β T cells has been controversial, and their molecular drivers remain undefined. Here, we report that specific deletion of bone-producing osteocalcin (Ocn)-expressing cells in vivo markedly reduces T-competent progenitors and t...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Yu, Vionnie W.C., Saez, Borja, Cook, Colleen, Lotinun, Sutada, Pardo-Saganta, Ana, Wang, Ying-Hua, Lymperi, Stefania, Ferraro, Francesca, Raaijmakers, Marc H.G.P., Wu, Joy Y., Zhou, Lan, Rajagopal, Jayaraj, Kronenberg, Henry M., Baron, Roland, Scadden, David T.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419348/
https://ncbi.nlm.nih.gov/pubmed/25918341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141843
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