Platelets Direct Monocyte Differentiation Into Epithelioid-Like Multinucleated Giant Foam Cells With Suppressive Capacity Upon Mycobacterial Stimulation

Background. Epithelioid, foam, and multinucleated giant cells (MNGCs) are characteristics of tuberculosis granulomas, yet the precise genesis and functions of these transformed macrophages are unclear. We evaluated the role of platelets as drivers of macrophage transformation in mycobacterial infect...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Feng, Yonghong, Dorhoi, Anca, Mollenkopf, Hans-Joachim, Yin, Hongyun, Dong, Zhengwei, Mao, Ling, Zhou, Jun, Bi, Aixiao, Weber, Stephan, Maertzdorf, Jeroen, Chen, Gang, Chen, Yang, Kaufmann, Stefan H. E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224136/
https://ncbi.nlm.nih.gov/pubmed/24987031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu355
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