Monocyte progenitors give rise to multinucleated giant cells

The immune response to mycobacteria is characterized by granuloma formation, which features multinucleated giant cells as a unique macrophage type. We previously found that multinucleated giant cells result from Toll-like receptor-induced DNA damage and cell autonomous cell cycle modifications. Howe...

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Publicado no:Nat Commun
Main Authors: Lösslein, Anne Kathrin, Lohrmann, Florens, Scheuermann, Lisa, Gharun, Kourosh, Neuber, Jana, Kolter, Julia, Forde, Aaron James, Kleimeyer, Christian, Poh, Ying Yee, Mack, Matthias, Triantafyllopoulou, Antigoni, Dunlap, Micah D., Khader, Shabaana A., Seidl, Maximilian, Hölscher, Alexandra, Hölscher, Christoph, Guan, Xue Li, Dorhoi, Anca, Henneke, Philipp
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8016882/
https://ncbi.nlm.nih.gov/pubmed/33795674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22103-5
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