Monocyte progenitors give rise to multinucleated giant cells

The immune response to mycobacteria is characterized by granuloma formation, which features multinucleated giant cells as a unique macrophage type. We previously found that multinucleated giant cells result from Toll-like receptor-induced DNA damage and cell autonomous cell cycle modifications. Howe...

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發表在:Nat Commun
Main Authors: Lösslein, Anne Kathrin, Lohrmann, Florens, Scheuermann, Lisa, Gharun, Kourosh, Neuber, Jana, Kolter, Julia, Forde, Aaron James, Kleimeyer, Christian, Poh, Ying Yee, Mack, Matthias, Triantafyllopoulou, Antigoni, Dunlap, Micah D., Khader, Shabaana A., Seidl, Maximilian, Hölscher, Alexandra, Hölscher, Christoph, Guan, Xue Li, Dorhoi, Anca, Henneke, Philipp
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8016882/
https://ncbi.nlm.nih.gov/pubmed/33795674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22103-5
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