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Gene Body Methylation can alter Gene Expression and is a Therapeutic Target in Cancer
DNA methylation in promoters is well known to silence genes and is the presumed therapeutic target of methylation inhibitors. Gene body methylation is positively correlated with expression yet its function is unknown. We show that 5-aza-2'-deoxycytidine treatment not only reactivates genes but...
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| Publicado en: | Cancer Cell |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4224113/ https://ncbi.nlm.nih.gov/pubmed/25263941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.07.028 |
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