Extracellular Signal-Regulated Kinase 5 and Cyclic AMP Response Element Binding Protein Are Novel Pathways Inhibited by Vandetanib (ZD6474) and Doxorubicin in Mesotheliomas

Malignant mesothelioma (MM), lung cancers, and asbestosis are hyperproliferative diseases associated with exposures to asbestos. All have a poor prognosis; thus, the need to develop novel and effective therapies is urgent. Vandetanib (Van) (ZD6474, ZACTIMA) is a tyrosine kinase inhibitor that has sh...

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書目詳細資料
發表在:Am J Respir Cell Mol Biol
Main Authors: Sayan, Mutlay, Shukla, Arti, MacPherson, Maximilian B., Macura, Sherrill L., Hillegass, Jedd M., Perkins, Timothy N., Thompson, Joyce K., Beuschel, Stacie L., Miller, Jill M., Mossman, Brooke T.
格式: Artigo
語言:Inglês
出版: American Thoracic Society 2014
主題:
Translational Review
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224081/
https://ncbi.nlm.nih.gov/pubmed/24940987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0373TR
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