Extracellular Signal-Regulated Kinase 5 and Cyclic AMP Response Element Binding Protein Are Novel Pathways Inhibited by Vandetanib (ZD6474) and Doxorubicin in Mesotheliomas

Malignant mesothelioma (MM), lung cancers, and asbestosis are hyperproliferative diseases associated with exposures to asbestos. All have a poor prognosis; thus, the need to develop novel and effective therapies is urgent. Vandetanib (Van) (ZD6474, ZACTIMA) is a tyrosine kinase inhibitor that has sh...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Am J Respir Cell Mol Biol
Main Authors: Sayan, Mutlay, Shukla, Arti, MacPherson, Maximilian B., Macura, Sherrill L., Hillegass, Jedd M., Perkins, Timothy N., Thompson, Joyce K., Beuschel, Stacie L., Miller, Jill M., Mossman, Brooke T.
Formato: Artigo
Idioma:Inglês
Publicado: American Thoracic Society 2014
Assuntos:
Translational Review
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224081/
https://ncbi.nlm.nih.gov/pubmed/24940987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0373TR
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares