Extracellular Signal-Regulated Kinase 5 and Cyclic AMP Response Element Binding Protein Are Novel Pathways Inhibited by Vandetanib (ZD6474) and Doxorubicin in Mesotheliomas

Malignant mesothelioma (MM), lung cancers, and asbestosis are hyperproliferative diseases associated with exposures to asbestos. All have a poor prognosis; thus, the need to develop novel and effective therapies is urgent. Vandetanib (Van) (ZD6474, ZACTIMA) is a tyrosine kinase inhibitor that has sh...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Respir Cell Mol Biol
Prif Awduron: Sayan, Mutlay, Shukla, Arti, MacPherson, Maximilian B., Macura, Sherrill L., Hillegass, Jedd M., Perkins, Timothy N., Thompson, Joyce K., Beuschel, Stacie L., Miller, Jill M., Mossman, Brooke T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Thoracic Society 2014
Pynciau:
Translational Review
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224081/
https://ncbi.nlm.nih.gov/pubmed/24940987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0373TR
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