Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin

BACKGROUND: Malignant mesotheliomas (MM) have a poor prognosis, largely because of their chemoresistance to anti-cancer drugs such as doxorubicin (Dox). Here we show using human MM lines that Dox activates extracellular signal-regulated kinases (ERK1 and 2), causally linked to increased expression o...

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Bibliographic Details
Main Authors:	Shukla, Arti, Hillegass, Jedd M, MacPherson, Maximilian B, Beuschel, Stacie L, Vacek, Pamela M, Pass, Harvey I, Carbone, Michele, Testa, Joseph R, Mossman, Brooke T
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2010
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3016286/ https://ncbi.nlm.nih.gov/pubmed/21159167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-314
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Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin

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