Total chemical synthesis of a ribozyme derived from a group I intron.
We describe the complete chemical synthesis of a ribozyme that catalyzes template-directed oligonucleotide ligation. The specific activity of the synthetic ribozyme is nearly identical to that of the same enzyme generated by in vitro transcription with T7 RNA polymerase. The ribozyme is derived from...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1995
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42238/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7708666/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.7.2465 |
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