Histone trimethylation at H3K4, H3K9 and H4K20 correlates with patient survival and tumor recurrence in early-stage colon cancer

BACKGROUND: Post-translational modification of histone tails by methylation plays an important role in tumorigenesis. In this study, we investigated the nuclear expression of H3K4me3, H3K9me3 and H4K20me3 in early-stage colon cancer in relation to clinical outcome. METHODS: Tumor tissue cores of 254...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Benard, Anne, Goossens-Beumer, Inès J, van Hoesel, Anneke Q, de Graaf, Wouter, Horati, Hamed, Putter, Hein, Zeestraten, Eliane CM, van de Velde, Cornelis JH, Kuppen, Peter JK
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223547/
https://ncbi.nlm.nih.gov/pubmed/25047223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-531
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