p75 Regulates Purkinje Cell Firing by Modulating SK Channel Activity through Rac1

p75 is expressed among Purkinje cells in the adult cerebellum, but its function has remained obscure. Here we report that p75 is involved in maintaining the frequency and regularity of spontaneous firing of Purkinje cells. The overall spontaneous firing activity of Purkinje cells was increased in p7...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Tian, JinBin, Tep, Chhavy, Benedick, Alex, Saidi, Nabila, Ryu, Jae Cheon, Kim, Mi Lyang, Sadasivan, Shankar, Oberdick, John, Smeyne, Richard, Zhu, Michael X., Yoon, Sung Ok
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2014
Sujets:
Neurobiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223344/
https://ncbi.nlm.nih.gov/pubmed/25253694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.589937
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