Brain-derived Neurotrophic Factor (BDNF) Induces Polarized Signaling of Small GTPase (Rac1) Protein at the Onset of Schwann Cell Myelination through Partitioning-defective 3 (Par3) Protein

Brain-derived neurotrophic factor (BDNF) was shown to play a role in Schwann cell myelination by recruiting Par3 to the axon-glial interface, but the underlying mechanism has remained unclear. Here we report that Par3 regulates Rac1 activation by BDNF but not by NRG1-Type III in Schwann cells, altho...

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Autori principali: Tep, Chhavy, Kim, Mi Lyang, Opincariu, Laura I., Limpert, Allison S., Chan, Jonah R., Appel, Bruce, Carter, Bruce D., Yoon, Sung Ok
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256919/
https://ncbi.nlm.nih.gov/pubmed/22128191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.312736
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