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Increased Spinal Cord Na(+)-K(+)-2Cl(−) Cotransporter-1 (NKCC1) Activity Contributes to Impairment of Synaptic Inhibition in Paclitaxel-induced Neuropathic Pain
Microtubule-stabilizing agents, such as paclitaxel (Taxol), are effective chemotherapy drugs for treating many cancers, and painful neuropathy is a major dose-limiting adverse effect. Cation-chloride cotransporters, such as Na(+)-K(+)-2Cl(−) cotransporter-1 (NKCC1) and K(+)-Cl(−) cotransporter-2 (KC...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4223315/ https://ncbi.nlm.nih.gov/pubmed/25253692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.600320 |
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