A20 Regulates Atherogenic Interferon (IFN)-γ Signaling in Vascular Cells by Modulating Basal IFNβ Levels

IFNγ signaling in endothelial (EC) and smooth muscle cells (SMC) is a key culprit of pathologic vascular remodeling. The impact of NF-κB inhibitory protein A20 on IFNγ signaling in vascular cells remains unknown. In gain- and loss-of-function studies, A20 inversely regulated expression of IFNγ-induc...

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Vydáno v:J Biol Chem
Hlavní autoři: Moll, Herwig P., Lee, Andy, Minussi, Darlan C., da Silva, Cleide G., Csizmadia, Eva, Bhasin, Manoj, Ferran, Christiane
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223299/
https://ncbi.nlm.nih.gov/pubmed/25217635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.591966
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