The Folding of the Specific DNA Recognition Subdomain of the Sleeping Beauty Transposase Is Temperature-Dependent and Is Required for Its Binding to the Transposon DNA

The reaction of DNA transposition begins when the transposase enzyme binds to the transposon DNA. Sleeping Beauty is a member of the mariner family of DNA transposons. Although it is an important tool in genetic applications and has been adapted for human gene therapy, its molecular mechanism remain...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Leighton, Gage O., Konnova, Tatiana A., Idiyatullin, Bulat, Hurr, Sophia H., Zuev, Yuriy F., Nesmelova, Irina V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222973/
https://ncbi.nlm.nih.gov/pubmed/25375127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112114
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