Transcriptomic Changes Triggered by Hypoxia: Evidence for HIF-1α -Independent, [Na(+)](i)/[K(+)](i)-Mediated, Excitation-Transcription Coupling

This study examines the relative impact of canonical hypoxia-inducible factor-1alpha- (HIF-1α and Na(+) (i)/K(+) (i)-mediated signaling on transcriptomic changes evoked by hypoxia and glucose deprivation. Incubation of RASMC in ischemic conditions resulted in ∼3-fold elevation of [Na(+)](i) and 2-fo...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Koltsova, Svetlana V., Shilov, Boris, Birulina, Julia G., Akimova, Olga A., Haloui, Mounsif, Kapilevich, Leonid V., Gusakova, Svetlana V., Tremblay, Johanne, Hamet, Pavel, Orlov, Sergei N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222758/
https://ncbi.nlm.nih.gov/pubmed/25375852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110597
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