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Protein Engineering of the N-Terminus of NEMO: Structure Stabilization and Rescue of IKKβ Binding
[Image: see text] NEMO is a scaffolding protein that, together with the catalytic subunits IKKα and IKKβ, plays an essential role in the formation of the IKK complex and in the activation of the canonical NF-κB pathway. Rational drug design targeting the IKK-binding site on NEMO would benefit from s...
Enregistré dans:
| Publié dans: | Biochemistry |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American
Chemical Society
2014
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4222529/ https://ncbi.nlm.nih.gov/pubmed/25286246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500861x |
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