Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL

A major barrier to the clinical use of erythrocytes generated in vitro from pluripotent stem cells or cord blood progenitors is failure of these erythrocytes to express adult hemoglobin. The key regulators of globin switching KLF1 and BCL11A are absent or at a lower level than in adult cells in K562...

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Publicado no:Haematologica
Main Authors: Trakarnsanga, Kongtana, Wilson, Marieangela C., Lau, Winnie, Singleton, Belinda K., Parsons, Steve F., Sakuntanaga, Punthita, Kurita, Ryo, Nakamura, Yukio, Anstee, David J., Frayne, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222483/
https://ncbi.nlm.nih.gov/pubmed/25107887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2014.110155
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