Gene silencing of heparanase results in suppression of invasion and migration of hepatoma cells

BACKGROUND: This study investigated the effect of transcriptional gene silencing (TGS) of the heparanase gene on hepatoma SMCC-7721 cells. METHODS: SiRNAs targeting the promoter region and coding region of the heparanase gene were designed and synthesized. Then the siRNAs were transfected into hepat...

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Veröffentlicht in:World J Surg Oncol
Hauptverfasser: Dong, Weiwei, Zhao, Huixia, Zhang, Caihong, Geng, Paili, Sarengaowa,  , Li, Qiuwen, Zhu, Jianhua, Li, Guanghui, Zhang, Shufang, Ye, Ming, Xiao, Wenhua
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222455/
https://ncbi.nlm.nih.gov/pubmed/25185798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-7819-12-85
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