Downregulation of MHC-I expression is prevalent but reversible in Merkel cell carcinoma

Merkel cell carcinoma (MCC) is an aggressive, polyomavirus-associated skin cancer. Robust cellular immune responses are associated with excellent outcomes in MCC patients, but these responses are typically absent. We determined the prevalence and reversibility of class I MHC (MHC-I) downregulation i...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Paulson, Kelly G., Tegeder, Andrew, Willmes, Christoph, Iyer, Jayasri G, Afanasiev, Olga K., Schrama, David, Koba, Shinichi, Thibodeau, Renee, Nagase, Kotaro, Simonson, William T, Seo, Aaron, Koelle, David M., Madeleine, Margaret, Bhatia, Shailender, Nakajima, Hideki, Sano, Shigetoshi, Hardwick, James S., Disis, Mary L., Cleary, Michele A, Becker, Jürgen C., Nghiem, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221542/
https://ncbi.nlm.nih.gov/pubmed/25116754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0005
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