Downregulation of MHC-I expression is prevalent but reversible in Merkel cell carcinoma

Merkel cell carcinoma (MCC) is an aggressive, polyomavirus-associated skin cancer. Robust cellular immune responses are associated with excellent outcomes in MCC patients, but these responses are typically absent. We determined the prevalence and reversibility of class I MHC (MHC-I) downregulation i...

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Bibliografiska uppgifter
I publikationen:Cancer Immunol Res
Huvudupphovsmän: Paulson, Kelly G., Tegeder, Andrew, Willmes, Christoph, Iyer, Jayasri G, Afanasiev, Olga K., Schrama, David, Koba, Shinichi, Thibodeau, Renee, Nagase, Kotaro, Simonson, William T, Seo, Aaron, Koelle, David M., Madeleine, Margaret, Bhatia, Shailender, Nakajima, Hideki, Sano, Shigetoshi, Hardwick, James S., Disis, Mary L., Cleary, Michele A, Becker, Jürgen C., Nghiem, Paul
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221542/
https://ncbi.nlm.nih.gov/pubmed/25116754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0005
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