Downregulation of MHC-I expression is prevalent but reversible in Merkel cell carcinoma

Merkel cell carcinoma (MCC) is an aggressive, polyomavirus-associated skin cancer. Robust cellular immune responses are associated with excellent outcomes in MCC patients, but these responses are typically absent. We determined the prevalence and reversibility of class I MHC (MHC-I) downregulation i...

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Bibliografske podrobnosti
izdano v:Cancer Immunol Res
Main Authors: Paulson, Kelly G., Tegeder, Andrew, Willmes, Christoph, Iyer, Jayasri G, Afanasiev, Olga K., Schrama, David, Koba, Shinichi, Thibodeau, Renee, Nagase, Kotaro, Simonson, William T, Seo, Aaron, Koelle, David M., Madeleine, Margaret, Bhatia, Shailender, Nakajima, Hideki, Sano, Shigetoshi, Hardwick, James S., Disis, Mary L., Cleary, Michele A, Becker, Jürgen C., Nghiem, Paul
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221542/
https://ncbi.nlm.nih.gov/pubmed/25116754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0005
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