Caspase-1/ASC Inflammasome-Mediated Activation of IL-1β–ROS–NF-κB Pathway for Control of Trypanosoma cruzi Replication and Survival Is Dispensable in NLRP3(−/−) Macrophages

In this study, we have utilized wild-type (WT), ASC(−/−), and NLRP3(−/−) macrophages and inhibition approaches to investigate the mechanisms of inflammasome activation and their role in Trypanosoma cruzi infection. We also probed human macrophages and analyzed published microarray datasets from huma...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Dey, Nilay, Sinha, Mala, Gupta, Shivali, Gonzalez, Mariela Natacha, Fang, Rong, Endsley, Janice J., Luxon, Bruce A., Garg, Nisha Jain
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221042/
https://ncbi.nlm.nih.gov/pubmed/25372293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111539
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