SMAD signaling regulates CXCL12 expression in the bone marrow niche, affecting homing and mobilization of hematopoietic progenitors

We recently demonstrated that ex vivo activation of SMAD-independent BMP4 signaling in hematopoietic stem/progenitor cells (HSPCs) influences their homing into the bone marrow (BM). We here assessed if alterations in BMP signaling in vivo affects adult hematopoiesis by affecting the BM niche. We dem...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: Khurana, Satish, Melacarne, Alessia, Yadak, Rana, Schouteden, Sarah, Notelaers, Tineke, Pistoni, Mariaelena, Maes, Christa, Verfaillie, Catherine M
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220608/
https://ncbi.nlm.nih.gov/pubmed/25069965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1794
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