SMAD signaling regulates CXCL12 expression in the bone marrow niche, affecting homing and mobilization of hematopoietic progenitors

We recently demonstrated that ex vivo activation of SMAD-independent BMP4 signaling in hematopoietic stem/progenitor cells (HSPCs) influences their homing into the bone marrow (BM). We here assessed if alterations in BMP signaling in vivo affects adult hematopoiesis by affecting the BM niche. We dem...

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Bibliografiske detaljer
Udgivet i:Stem Cells
Main Authors: Khurana, Satish, Melacarne, Alessia, Yadak, Rana, Schouteden, Sarah, Notelaers, Tineke, Pistoni, Mariaelena, Maes, Christa, Verfaillie, Catherine M
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220608/
https://ncbi.nlm.nih.gov/pubmed/25069965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1794
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