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Kinesin-14 and kinesin-5 antagonistically regulate microtubule nucleation by γ-TuRC in yeast and human cells

Bipolar spindle assembly is a critical control point for initiation of mitosis through nucleation and organization of spindle microtubules and is regulated by kinesin-like proteins. In fission yeast, the kinesin-14 Pkl1 binds the γ-tubulin ring complex (γ-TuRC) microtubule-organizing centre at spind...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Olmsted, Zachary T., Colliver, Andrew G., Riehlman, Timothy D., Paluh, Janet L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220466/
https://ncbi.nlm.nih.gov/pubmed/25348260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6339
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