Controlling for population structure and genotyping platform bias in the eMERGE multi-institutional biobank linked to electronic health records

Combining samples across multiple cohorts in large-scale scientific research programs is often required to achieve the necessary power for genome-wide association studies. Controlling for genomic ancestry through principal component analysis (PCA) to address the effect of population stratification i...

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Publicado en:Front Genet
Autores principales: Crosslin, David R., Tromp, Gerard, Burt, Amber, Kim, Daniel S., Verma, Shefali S., Lucas, Anastasia M., Bradford, Yuki, Crawford, Dana C., Armasu, Sebastian M., Heit, John A., Hayes, M. Geoffrey, Kuivaniemi, Helena, Ritchie, Marylyn D., Jarvik, Gail P., de Andrade, Mariza
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2014
Materias:
Genetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220165/
https://ncbi.nlm.nih.gov/pubmed/25414722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2014.00352
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