Controlling for population structure and genotyping platform bias in the eMERGE multi-institutional biobank linked to electronic health records

Combining samples across multiple cohorts in large-scale scientific research programs is often required to achieve the necessary power for genome-wide association studies. Controlling for genomic ancestry through principal component analysis (PCA) to address the effect of population stratification i...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Crosslin, David R., Tromp, Gerard, Burt, Amber, Kim, Daniel S., Verma, Shefali S., Lucas, Anastasia M., Bradford, Yuki, Crawford, Dana C., Armasu, Sebastian M., Heit, John A., Hayes, M. Geoffrey, Kuivaniemi, Helena, Ritchie, Marylyn D., Jarvik, Gail P., de Andrade, Mariza
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220165/
https://ncbi.nlm.nih.gov/pubmed/25414722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2014.00352
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