Establishment of a novel cell-based assay for screening small molecule antagonists of human interleukin-6 receptor

AIM: Blockade of interleukin-6 (IL-6) or its receptor (IL-6R) is effective in preventing the progression of autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis. In the present study, we established a novel cell-based assay for identifying small molecule IL-6R antagonis...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: He, Yang-yang, Yan, Yu, Zhang, Chang, Li, Peng-yuan, Wu, Ping, Du, Peng, Zeng, Da-di, Fang, Jian-song, Wang, Shuang, Du, Guan-hua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220080/
https://ncbi.nlm.nih.gov/pubmed/25345743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.90
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