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In situ hybridization assay-based small molecule screening in zebrafish
In vitro biochemical and cell-based small molecule screens have been widely used to identify compounds that target specific signaling pathways. But the identified compounds frequently fail at the animal testing stage, largely due to the in vivo absorption, metabolism and toxicity of chemicals. Zebra...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3447532/ https://ncbi.nlm.nih.gov/pubmed/23001521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/9780470559277.ch110236 |
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