Inhibition of Acidic Sphingomyelinase Reduces Established Hepatic Fibrosis in Mice

AIMS: Liver fibrosis occurs as a result of several chronic liver diseases and leads to portal hypertension, cirrhosis and liver failure, often requiring liver transplantation. Activated hepatic stellate cells (HSC) are known to contribute to liver fibrosis, but currently there are no effective thera...

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Gepubliceerd in:Hepatol Res
Hoofdauteurs: Quillin, Ralph C, Wilson, Gregory C, Nojima, Hiroyuki, Freeman, Christopher H, Wang, Jiang, Schuster, Rebecca M, Blanchard, John A, Edwards, Michael J, Gandhi, Chandrashekhar R, Gulbins, Erich, Lentsch, Alex B
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4219935/
https://ncbi.nlm.nih.gov/pubmed/24796378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/hepr.12352
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