Stress-Induced Increase in Kynurenic Acid as a Potential Biomarker for Patients With Schizophrenia and Distress Intolerance

IMPORTANCE: Several lines of evidence have linked the endogenous neuromodulator kynurenic acid (KYNA) to schizophrenia. The pathophysiology of schizophrenia is commonly associated with stress, and stress plays a key regulatory role in the first, rate-limiting step of the kynurenine pathway, which pr...

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Udgivet i:JAMA Psychiatry
Main Authors: Chiappelli, Joshua, Pocivavsek, Ana, Nugent, Katie L., Notarangelo, Francesca M., Kochunov, Peter, Rowland, Laura M., Schwarcz, Robert, Hong, L. Elliot
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4219570/
https://ncbi.nlm.nih.gov/pubmed/24806441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamapsychiatry.2014.243
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