Pulsed high intensity focused ultrasound increases penetration and therapeutic efficacy of monoclonal antibodies in murine xenograft tumors

The success of radioimmunotherapy for solid tumors remains elusive due to poor biodistribution and insufficient tumor accumulation, in part, due to the unique tumor microenvironment resulting in heterogeneous tumor antibody distribution. Pulsed high intensity focused ultrasound (pulsed-HIFU) has pre...

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Dettagli Bibliografici
Pubblicato in:J Control Release
Autori principali: Wang, Shutao, Shin, In Soo, Hancock, Hilary, Jang, Beom-su, Kim, Hyung-sub, Lee, Sang Myung, Zderic, Vesna, Frenkel, Victor, Pastan, Ira, Paik, Chang H., Dreher, Matthew R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4219504/
https://ncbi.nlm.nih.gov/pubmed/22732476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2012.06.025
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