Pulsed high intensity focused ultrasound increases penetration and therapeutic efficacy of monoclonal antibodies in murine xenograft tumors

The success of radioimmunotherapy for solid tumors remains elusive due to poor biodistribution and insufficient tumor accumulation, in part, due to the unique tumor microenvironment resulting in heterogeneous tumor antibody distribution. Pulsed high intensity focused ultrasound (pulsed-HIFU) has pre...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Wang, Shutao, Shin, In Soo, Hancock, Hilary, Jang, Beom-su, Kim, Hyung-sub, Lee, Sang Myung, Zderic, Vesna, Frenkel, Victor, Pastan, Ira, Paik, Chang H., Dreher, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4219504/
https://ncbi.nlm.nih.gov/pubmed/22732476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2012.06.025
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