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Wild Type Bone Marrow Transplant Partially Reverses Neuroinflammation in Progranulin-Deficient Mice

Frontotemporal dementia (FTD) is a neurodegenerative disease with devastating changes in behavioral performance and social function. Mutations in the progranulin gene (GRN) are one of the most common causes of inherited FTD due to reduced progranulin expression or activity, including in brain where...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Lab Invest
Hauptverfasser: Yang, Yue, Aloi, Macarena S., Cudaback, Eiron, Josephsen, Samuel R., Rice, Samantha J., Jorstad, Nikolas L., Keene, C. Dirk, Montine, Thomas J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218738/
https://ncbi.nlm.nih.gov/pubmed/25199051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2014.113
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