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NT-39 GLUTAMINASE-MEDIATED METABOLIC PATHWAY INVOLVES GLIOBLASTOMA RESISTANCE TO mTOR-TARGETED THERAPIES
BACKGROUND: Although the phosphatidylinositol 3-kinase (PI3K)/ mammalian target of rapamycin (mTOR) pathway is a master regulator of aerobic glycolysis and cellular biosynthesis, the effect of modulating mTOR activity on other metabolic processes, such as glutamine metabolism is not well understood....
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4218448/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou265.37 |
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