NT-39 GLUTAMINASE-MEDIATED METABOLIC PATHWAY INVOLVES GLIOBLASTOMA RESISTANCE TO mTOR-TARGETED THERAPIES

BACKGROUND: Although the phosphatidylinositol 3-kinase (PI3K)/ mammalian target of rapamycin (mTOR) pathway is a master regulator of aerobic glycolysis and cellular biosynthesis, the effect of modulating mTOR activity on other metabolic processes, such as glutamine metabolism is not well understood....

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Hauptverfasser: Tanaka, Kazuhiro, Sasayama, Takashi, Irino, Yasuhiro, Takata, Kumi, Nagashima, Hiroaki, Masui, Kenta, Gini, Beatrice, Yang, Huijun, Mischel, Paul S., Kohmura, Eiji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218448/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou265.37
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