NT-33 NAD+ SYNTHESIS INHIBITION AS A THERAPEUTIC STRATEGY FOR GLIOBLASTOMA WITH MYC AMPLIFICATION

BACKGROUND AND OBJECTIVE: Oncoprotein Myc is a master transcription factor and plays a crucial role in human cancer pathogenesis and the stem-like phenotype of glioblastoma (GBM). Since dyregulated Myc in cancer drives altered glucose and glutamine metabolism promoting tumor growth, pathways involve...

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Bibliografiset tiedot
Päätekijät: Tateishi, Kensuke, Lelic, Nina, Ho, Quan H., Esakl, Shinichi, Iafrate, John A., Cahill, Daniel P., Chi, Andrew S., Wakimoto, Hiroaki
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2014
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Abstracts
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218442/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou265.31
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