NI-57 DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE PERFUSION WEIGHTED IMAGING (DCE-MRI) AND DIFFUSION WEIGHTED IMAGING (DWI) FOR PHARMACODYNAMIC EVALUATION OF CARBOXYAMIDOTRIAZOLE OROTATE (CTO) AND TEMOZOLOMIDE IN MALIGNANT GLIOMA

BACKGROUND: Advanced imaging techniques have been proposed as potentially useful tools for evaluation of biological effects of new targeted agents. CTO is an oral inhibitor of non-voltage-dependent calcium signaling that modulates several pathways, including EGFR, MEK, RAS, HDAC, HSP90, WNT/B-cateni...

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Autors principals: Magge, Rajiv, Perez, Julio Arevalo, Young, Robert, Kaley, Thomas, Pentsova, Elena, DeAngelis, Lisa, Diamond, Eli, Mellinghoff, Ingo, Peck, Kyung, Anderson, Barry, Gorman, Greg, Mclean, Sean, Karmali, Rashida, Omuro, Antonio
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218384/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou264.55
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