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ET-42 DEVELOPMENT OF A NOVEL, FUNCTION-BLOCKING ANTI-FIBULIN-3 ANTIBODY AS TARGETED REAGENT FOR GLIOBLASTOMA
Fibulin-3 is a protein secreted by glioblastoma (GBM) cells that is virtually absent in normal brain. This protein promotes tumor invasion and, more unusually, apoptotic resistance, by paracrine activation of Notch and NFkB pathways (see companion abstract). Conditional knockdown of fibulin-3 reduce...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4218140/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou255.42 |
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