Activation of Ca2+ signaling in neutrophils by the mast cell-released immunophilin FKBP12.
The immunophilins of the FK506-binding protein (FKBP) family are intracellular proteins that bind the immunosuppresants FK506 and rapamycin. In this study we show that HMC-1 mast cells sensitized with IgE release FKBP12 upon stimulation with anti-IgE. The release is rapid and not affected by actinom...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1995
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42181/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7536932/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.8.3435 |
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