DD-03 THE NATURALLY OCCURRING STEROID, WITHAFERIN A, IN SYNERGISTIC CONCERT WITH HER2/EGFR INHIBITORS ABROGATES PROLIFERATION OF HUMAN GLIOBLASTOMA CELL CULTURES AT NANOMOLAR CONCENTRATIONS

INTRODUCTION: Withaferin A, a steroidal lactone that is isolated from the winter cherry (Withania sominifera), confers abrogatory effects on proliferating cancer cells. This is achieved, partly though Withaferin A's ability to retard angiogenesis along with VEGF and calcium signaling. At the le...

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Main Authors: Chang, Edwin, Abbasi, Taher, D'Souza, Aloma, Gowrishankar, Gayatri, Mallick, Parag, Gambhir, Sanjiv S.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218033/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou246.3
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